Overview

In this trial, investigators are testing whether or not green light exposure can help reduce epileptic spikes for people with medically-refractory epilepsy. The study will test how safe, tolerable, and effective this treatment is for people with epilepsy.

Study Information

In this study, 16 participants will undergo 120 minutes of a narrow band of green light (520-540 nm) at low intensities that are known to be tolerable for adults and children. Participants will undergo a 30 minute scalp EEG test before and after the exposure to monitor spike frequency and see if there is a change in epileptic spikes per minute.

Inclusion Criteria

• Ages 6 months-30 years
• Epileptic spike frequency ≥1 epileptic spike per minute at baseline, as determined by scalp EEG recording
• Admitted to the Boston Children’s Hospital Epilepsy Long Term Monitoring Unit at the time of enrollment

Exclusion Criteria

• Cataracts
• Retinol disease
• Any history of or currently not well controlled ophthalmic disease that prevents transmission from the retina to the optic nerve
• Clinical seizure 4 hours or less before anticipated green light exposure

Location

Boston Children’s Hospital

Boston, Massachusetts, United States, 02130

Contact: Harper L Kaye    617-355-4875 neuromodulation@childrens.harvard.edu  

Principal Investigator: Alexander Rotenberg, MD, Ph D        

Principal Investigator: Phillip Pearl, MD        

Sub-Investigator: Harper L Kaye

Sponsors/Collaborators

Boston Children’s Hospital