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Effects of Green Light Exposure on Epileptic Spikes in Patients With Refractory Epilepsy

January 2, 2020


In this trial, investigators are testing whether or not green light exposure can help reduce epileptic spikes for people with medically-refractory epilepsy. The study will test how safe, tolerable, and effective this treatment is for people with epilepsy.


Study Information

In this study, 16 participants will undergo 120 minutes of a narrow band of green light (520-540 nm) at low intensities that are known to be tolerable for adults and children. Participants will undergo a 30 minute scalp EEG test before and after the exposure to monitor spike frequency and see if there is a change in epileptic spikes per minute.


Inclusion Criteria


  • Ages 6 months-30 years
  • Epileptic spike frequency ≥1 epileptic spike per minute at baseline, as determined by scalp EEG recording
  • Admitted to the Boston Children’s Hospital Epilepsy Long Term Monitoring Unit at the time of enrollment


Exclusion Criteria


  • Cataracts
  • Retinol disease
  • Any history of or currently not well controlled ophthalmic disease that prevents transmission from the retina to the optic nerve
  • Clinical seizure 4 hours or less before anticipated green light exposure



Boston Children’s Hospital

Boston, Massachusetts, United States, 02130

Contact: Harper L Kaye    617-355-4875  

Principal Investigator: Alexander Rotenberg, MD, Ph D        

Principal Investigator: Phillip Pearl, MD        

Sub-Investigator: Harper L Kaye



Boston Children’s Hospital

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